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筑波大学数理物質系 長崎研究室 研究成果 |
学会発表動画
●2022.12.6 SFRR Australasia & Japan Conference in Christchurch, New Zealand (25.14)
本動画はSFRR Australasia & Japan Conference, 5–7 December 2022 in Christchurch, New Zealand (https://www.otago.ac.nz/free-radical/research/otago840968.htm)における発表内容を記録したものです。我々が開発してきた自己組織化型抗酸化剤(RNP)は腸内に選択的に集積し、長時間にわたって過剰の活性酸素種(ROS)を消去することで、鬱病を改善することが出来ると言うことを明らかにしました。これは今話題の脳腸相関による効果が現れていることを示すものです。 脳が腸に指令を出すとともに腸が脳に対して影響する事が様々調べられていますが、我々が知る限り、腸内環境を改善して鬱病が治ることを示した初めての例です。また、アスリートや強い運動をする人たちの間で消化管に障害が起こる運動性胃腸症候群(EIGS)が話題になっております。我々の自己組織化抗酸化剤(RNP)の投与で腸の炎症を抑制し、運動能力を飛躍的に向上させることを明らかにしました。
●2022.11.15 第二回腸内デザイン学会(Online) (18.12)
我々が作製してきた分子組織化薬は腸内の炎症を抑制し、これが鬱病の改善や運動能向上に高い効果を示します。また、酪酸やγアミノ酪酸を腸内に放出することで脂肪肝・肝線維化や糖尿病を改善し、鬱病を改善しました。
●2022.11.12 第３３回腎とフリーラジカル研究会(茨城県県南生涯学習センター、土浦)(12.54)
腸内の活性酸素種(ROS)を選択的に消去する自己組織化型抗酸化剤(RNP)は鬱病の改善や運動能の向上を示した。同時に赤血球のダメージや肝臓・腎臓機能のダメージを改選した。
●2022.11.05 10th Biennial Meeting of the Society for Free Radical Research-Asia (Seoul, Korea) (15.58)
We have designed self-assembling nanoparticle-type antioxidants (RNP). The oral administration of RNP only located in the GI tract and no internalization was observed in the bloodstream. The intestine-located RNP eliminated the intestinal ROS and recovered the inflammation, which recovered the depression tendency caused by the chronic restrain stress model mice. The oral administration of RNP also extended the all-out running time of high-stress running mice on the treadmill.
●2021.11.12 日本放射線腫瘍学会 第34回学術集会(オンライン)(6.58)
我々の抗酸化ナノ粒子(RNP)は腫瘍増殖抑制効果を減弱せず，副作用を著しく低減させた。QOLの高い放射線治療が期待される。
発表論文：Ahram Kim, Chiaki Yonemoto, Chitho P. Feliciano, Babita Shashni, and Yukio Nagasaki, Antioxidant nanomedicine significantly enhances the survival benefit of radiation cancer therapy by mitigating oxidative stress-induced side effects, Small, in press (10.1002/smll.202008210).
●2021.10.22-23 The 11th International Forum on Post-Genomic Technologies (IFPT’11) PART 1 (Online) (22.42)
-Antioxidant self-assembling drugs
●2021.10.22-23 The 11th International Forum on Post-Genomic Technologies (IFPT’11) PART 2 (Online) (27.45)
-Amino Acids based self-assembling drugs
-Shor Chain Fatty Acids based self-assembling drugs
l 2021.10.9 第36回糖尿病合併症学会
発表論文：Babita Shashni, Yuya Tajika, Yukio Nagasaki, Design of Enzyme-responsive Short-Chain Fatty Acid-based Self-Assembling Drug for Alleviation of Type 2 Diabetes Mellitus, Biomaterials, in press. (https://doi.org/10.1016/j.biomaterials.2021.120877).
l 2021.10.7 The 25th World Congress of Neurology
発表論文：Long Binh Vong, Yuna Sato, Pennapa Chonpathompikunlert, Supita Tanasawet, Pilaiwanwadee Hutamekalin, Yukio Nagasaki, Self-assembled polydopamine nanoparticles improve treatment in Parkinson's disease model mice and suppress dopamine-induced dyskinesia, Acta Biomaterialia, Volume 109, 220-228(2020) (doi: 10.1016/j.actbio.2020.03.021)
l 2021.9.24-26 第54回日本てんかん学会学術集会 「副作用の低減を可能にする長期徐放型高分子抗てんかん薬の開発」(9.11)
発表者：池田 豊
●2021.9.21 The 72th Divisional Meeting of Division of Colloid and Interface Chemistry, International Symposium, Plenary Lecture（Online）(47.31)
*Introduction of “Molecular Self-assembling Drugs” on antioxidants, amino acids and short chain fatty acids
●2021.9.17第72回コロイド及び界面科学討論会「特別企画1」生命科学とコロイド・界面科学（Online）(32.40)
*自己組織化抗酸化剤、アミノ酸型自己組織化薬、短鎖脂肪酸型自己組織化薬に関して最近の話題を紹介
l 2021.9.14 電気通信学会(IEICE)2021年ソサイエティ大会シンポジウム「先端バイオテクのリジーの医工展開」(37.02)
発表論文
ーToru Yoshitomi, Yukio Nagasaki, Self-assembling antioxidants for ischemia-reperfusion injuries, Antioxidants and Redox Signaling, Forum Article “REDOX THERANOSTICS”, accepted.
ーAhram Kim, Chiaki Yonemoto, Chitho P. Feliciano, Babita Shashni, and Yukio Nagasaki, Antioxidant nanomedicine significantly enhances the survival benefit of radiation cancer therapy by mitigating oxidative stress-induced side effects, Small, in press (10.1002/smll.202008210).
ーTakuto Toriumi, Ahram Kim, Shoichi Komine, Ikuru Miura, Suminori Nagayama, Hajime Ohmori, and Yukio Nagasaki, An Antioxidant Nanoparticle Enhances Exercise Performance in Rat High-intensity Running Models, Advanced Healthcare Materials, Volume10, Issue10 May 19, 2021 2100067 (doi.org/10.1002/adhm.202100067).
l 2021.9.14 第28回肝細胞研究会
l 2021.9.10 1st JCA-AACR Precision Cancer Medicine International Conference, On-line (5.20)
発表論文：Ahram Kim, Chiaki Yonemoto, Chitho P. Feliciano, Babita Shashni, and Yukio Nagasaki, Antioxidant nanomedicine significantly enhances the survival benefit of radiation cancer therapy by mitigating oxidative stress-induced side effects, Small, in press (10.1002/smll.202008210).
l 2021.9.7 第70回高分子討論会(高分子学会・オンライン) (14.42)
発表論文
*. Ahram Kim, Chiaki Yonemoto, Chitho P. Feliciano, Babita Shashni, and Yukio Nagasaki, Antioxidant nanomedicine significantly enhances the survival benefit of radiation cancer therapy by mitigating oxidative stress-induced side effects, Small, in press (10.1002/smll.202008210).
*.Takuto Toriumi, Ahram Kim, Shoichi Komine, Ikuru Miura, Suminori Nagayama, Hajime Ohmori, and Yukio Nagasaki, An Antioxidant Nanoparticle Enhances Exercise Performance in Rat High-intensity Running Models, Advanced Healthcare Materials, Volume10, Issue10 May 19, 2021 2100067 (doi.org/10.1002/adhm.202100067).
l 2021.8.19-21 European Society of Medicine Forum Review (21.15)
発表論文
*Toru Yoshitomi, Yukio Nagasaki, Self-assembling antioxidants for ischemia-reperfusion injuries, Antioxidants and Redox Signaling, Forum Article “REDOX THERANOSTICS”, in press (10.1089/ars.2021.0103).
*Babita Shashni, Yukio Nagasaki, Newly Developed Self-assembling Antioxidants as Potential Therapeutics for the Cancers, Journal of Personalized Medicine, Vol.11, 92 (2021)(https://doi.org/10.3390/jpm11020092)
l 2021.7.25-29 2021 CRS Virtual Annual Meeting (11.12)
Yukio Nagasaki, Babita Shashni, Yuya Tajika, Design of Short-Chain Fatty Acid-based Self-Assembling Drug for Alleviation of Type 2 Diabetes Mellitus
発表論文：Babita Shashni, Yuya Tajika, Yukio Nagasaki, Design of Enzyme-responsive Short-Chain Fatty Acid-based Self-Assembling Drug for Alleviation of Type 2 Diabetes Mellitus, Biomaterials, in press. (https://doi.org/10.1016/j.biomaterials.2021.120877).
l 2021.7.25-29 2021 CRS Virtual Annual Meeting (11.12)
Yukio Nagasaki, Ahram Kim, Chiaki Yonemoto, Chitho P. Feliciano, Babita Shashni, 3575778 Antioxidant nanoparticle improves radiation efficiency on cancer therapy
発表論文：Ahram Kim, Chiaki Yonemoto, Chitho P. Feliciano, Babita Shashni, and Yukio Nagasaki, Antioxidant nanomedicine significantly enhances the survival benefit of radiation cancer therapy by mitigating oxidative stress-induced side effects, Small, in press (10.1002/smll.202008210).
2021.7.24-26 2021 CRS Virtual Annual Meeting “Design of Short-Chain Fatty Acid-based Self-Assembling Drug for Alleviation of Type 2 Diabetes Mellitus”(7.17)
発表者: Babita Shashni
2021.7.5 高分子学会 第 50 回医用高分子シンポジウム「高分子ミセル型抗酸化薬は高強度走行能力を大幅に向上する」(3.01)
発表者：鳥海拓都(D2)
l 2021.7.5-6 第50回高分子学会医用高分子シンポジウム(On-line) (10.14)
「短鎖脂肪酸を放出する分子組織化薬の設計と糖尿病治療」
発表論文：Babita Shashni, Yuya Tajika, Yukio Nagasaki, Design of Enzyme-responsive Short-Chain Fatty Acid-based Self-Assembling Drug for Alleviation of Type 2 Diabetes Mellitus, Biomaterials, in press. (https://doi.org/10.1016/j.biomaterials.2021.120877).
l 2021.6.30第37回日本DDS学会学術集会(7.08)
「抗酸化剤の腫瘍へのデリバリーが放射線治療に及ぼす影響」
発表論文：Ahram Kim, Chiaki Yonemoto, Chitho P. Feliciano, Babita Shashni, and Yukio Nagasaki, Antioxidant nanomedicine significantly enhances the survival benefit of radiation cancer therapy by mitigating oxidative stress-induced side effects, Small, in press (10.1002/smll.202008210).
l 2021.6.30 第37回日本DDS学会学術集会（幕張メッセ・オンラインハイブリッド） Novel design of GABA-containing polymeric nanoparticles for the treatment of depression (6.59)
発表者：Bui Duc Tri (D2)
l 2021.6.25-27 第21回日本抗加齢医学会総会 (京都国際会議場・オンラインハイブリッド開催)(7.36)「ラット運動能力を飛躍的に向上させる新しいナノ粒子型抗酸化剤」
発表論文：Takuto Toriumi Ahram Kim Shoichi Komine Ikuru Miura Suminori Nagayama Hajime Ohmori and Yukio Nagasaki An Antioxidant Nanoparticle Enhances Exercise Performance in Rat High-intensity Running Models Advanced Healthcare Materials in press (doi.org/10.1002/adhm.202100067).
l 2021.6.25-27第21回日本抗加齢医学会総会 (京都国際会議場・オンラインハイブリッド開催)(6.39)腸内細菌叢で着目される酪酸を放出する分子組織化薬の設計と糖尿病治療
発表論文：Babita Shashni, Yuya Tajika, Yukio Nagasaki, Design of Enzyme-responsive Short-Chain Fatty Acid-based Self-Assembling Drug for Alleviation of Type 2 Diabetes Mellitus, Biomaterials, in press. (https://doi.org/10.1016/j.biomaterials.2021.120877).
l 2021.6.1 第25回腸内細菌学会学術集会(7.37)
「酪酸を放出する分子組織化薬の設計と糖尿病治療」
発表論文：Babita Shashni, Yuya Tajika, Yukio Nagasaki, Design of Enzyme-responsive Short-Chain Fatty Acid-based Self-Assembling Drug for Alleviation of Type 2 Diabetes Mellitus, Biomaterials, accepted.
l 2021.5.26 第70回高分子学会年次大会(12.48)
発表論文：Ahram Kim, Chiaki Yonemoto, Chitho P. Feliciano, Babita Shashni, and Yukio Nagasaki, Antioxidant nanomedicine significantly enhances the survival benefit of radiation cancer therapy by mitigating oxidative stress-induced side effects, Small, in press (10.1002/smll.202008210).
l 2021.5.22第62回日本神経学会学術大会 (9.44)
Poly(DOPA)-based nanoparticle prevents rapid excretion of DOPA and improves therapeutic performances (9.44)
代謝の速いL-DOPAに対して私たちが開発したNanoDOPAはバイオアベイラビリティーを延長することで効果を上げ、ディスキネジア等の副作用を低減することができます。
発表論文：Long Binh Vong, Yuna Sato, Pennapa Chonpathompikunlert, Supita Tanasawet, Pilaiwanwadee Hutamekalin, Yukio Nagasaki, Self-assembled polydopamine nanoparticles improve treatment in Parkinson's disease model mice and suppress dopamine-induced dyskinesia, Acta Biomaterialia, Volume 109, 220-228(2020) (doi: 10.1016/j.actbio.2020.03.021)
l 2021.5.20 第74回日本酸化ストレス学会・第21回日本NO学会合同学術集会(On-line) (11.03)
腫瘍内RIS消去はがん放射線治療効果を増強する
発表論文：Ahram Kim, Chiaki Yonemoto, Chitho P. Feliciano, Babita Shashni, and Yukio Nagasaki, Antioxidant nanomedicine significantly enhances the survival benefit of radiation cancer therapy by mitigating oxidative stress-induced side effects, Small, in press (10.1002/smll.202008210).
l 2021.2.22第14回パーキンソン病・運動障害疾患コングレス（On-line発表）(3.11)
分子組織化ナノ(ドーパ）効果を維持しつつ、副作用を低減する.
発表論文：Long Binh Vong, Yuna Sato, Pennapa Chonpathompikunlert, Supita Tanasawet, Pilaiwanwadee Hutamekalin, Yukio Nagasaki, Self-assembled polydopamine nanoparticles improve treatment in Parkinson's disease model mice and suppress dopamine-induced dyskinesia, Acta Biomaterialia, Volume 109, 220-228(2020) (doi: 10.1016/j.actbio.2020.03.021)
l 2020.11.26-27 高分子学会 第29回ポリマー材料フォーラム(PMF) (8.33)
長崎研の研究内容紹介
l 2020.9.16 第69回高分子学会高分子討論会 「脂肪肝炎(NASH)に対する短鎖脂肪酸型自己組織化薬の設計」(6.27)
発表者：田鹿裕也 (パブリシティー賞受賞）
l 2020.7.30 第30回バイオ・高分子研究会(高分子学会)（On-line発表）(16.05)
ポリペプチドをベースとする分子組織化薬の開発
発表論文：
①Long Binh Vong, Yuna Sato, Pennapa Chonpathompikunlert, Supita Tanasawet, Pilaiwanwadee Hutamekalin, Yukio Nagasaki, Self-assembled polydopamine nanoparticles improve treatment in Parkinson's disease model mice and suppress dopamine-induced dyskinesia, Acta Biomaterialia, Volume 109, 220-228(2020) (doi: 10.1016/j.actbio.2020.03.021)
②Long Binh Vong, Yota Ibayashi Yalosrav Lee, Dai-Nghiep Ngo, Yuji Nishikawa, Yukio Nagasaki, Poly(ornithine)-based self-assembling drug for recovery of hyperammonemia and damage in acute liver injury, Journal of Controlled Release, Vol.310, 74-81 (2019) (doi: 10.1016/j.jconrel.2019.08.011)
③Shinpei Kudo, Yukio Nagasaki, A Novel Nitric Oxide-based Anticancer therapeutics by Macrophage-targeted Poly(L-Arginine)-based Nanoparticles, Journal of Controlled Release, Vol. 217, 256–262(2015) (doi: 10.1016/j.jconrel.2015.09.019)